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Home » Our Product Range » Antimalarial Medicines


Antimalarial Medicines

Pioneers in the industry, we offer oseltamivir capsules, hydroxyurea capsules, fluoxetine hydrochloride capsules and isotretinoin capsules from India.

Oseltamivir Capsules

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Oseltamivir Capsules
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Product Details:
Packaging Size10 Capsules
Strength75 mg
CompositionOseltamivir
FormCapsule
TreatmentStuffy Nose, Cough, Sore Throat, Fever/Chills, Aches, Tiredness
Prescription/Non prescriptionPrescription
BrandAntiflu
ManufacturerCipla Ltd

Oseltamivir is an antiviral drug. It is an ethyl ester pro-drug, requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate.


The active metabolite is a selective inhibitor of influenza virus neuraminidase enzymes, which are glycoproteins found on the virion surface. Viral neuraminidase enzyme activity is important both for viral entry into uninfected cells and for the release of recently formed virus particles from infected cells, and for the further spread of infectious virus in the body.


Neuraminidase enzyme IC50 values for oseltamivir for clinically isolated influenza A ranged from 0.1 nM to 1.3 nM, and for influenza B was 2.6 nM. Higher IC50 values for influenza B, up to a median of 8.5 nM, have been observed in published studies.


The antiviral activity and neuraminidase inhibitory activity of oseltamivir carboxylate against laboratory strains and clinical isolates of influenza virus was determined in cell culture and biochemical assays. The concentrations of oseltamivir carboxylate required for inhibition of the influenza virus were highly variable, depending on the assay method used and the virus tested. The 50% and 90% effective concentrations (EC50 and EC90) were in the range of 0.0008 microM to >35 microM and 0.004 microM to >100 microM, respectively (1 microM = 0.284 mcg/mL). The relationship between the antiviral activity in cell culture and the inhibition of the influenza virus replication in humans has not been established.


Influenza A virus isolates with reduced susceptibility to oseltamivir carboxylate have been recovered by serial passage of virus in cell culture in the presence of increasing concentrations of oseltamivir carboxylate. Reduced susceptibility of influenza virus to inhibition by oseltamivir carboxylate may be conferred by amino acid substitutions in the viral neuraminidase and/or hemagglutinin proteins.


Reduced susceptibility isolates have been obtained during treatment with oseltamivir and from sampling during community surveillance studies. The clinical impact of this reduced susceptibility is unknown.


Hemagglutinin (HA) substitutions selected in cell culture and associated with reduced susceptibility to oseltamivir include (influenza virus subtype-specific numbering) A11T, K173G, and R453M in H3N2; and H99Q in influenza B virus (Yamagata lineage). In some cases, HA substitutions were selected in conjunction with known NA resistance substitutions and may contribute to reduced susceptibility to oseltamivir; however, the impact of HA substitutions on antiviral activity of oseltamivir in humans is unknown and likely to be strain dependent.


Selection of influenza A viruses resistant to oseltamivir can occur at higher frequencies in children. The incidence of oseltamivir treatment-associated resistance in paediatric treatment studies has been detected at rates of 27% to 37% and 3% to 18% (3/11 to 7/19 and 1/34 to 9/50 post-treatment isolates, respectively) for influenza A/H1N1 and influenza A/H3N2, respectively. The frequency of resistance selection to oseltamivir and the prevalence of such resistant virus vary seasonally and geographically.


Circulating seasonal influenza strains expressing neuraminidase resistance-associated substitutions have been observed in individuals who have not received oseltamivir treatment. The oseltamivir resistance-associated substitution H275Y was found in >99% of US/ Europe circulating 2008 H1N1 influenza isolates. The 2009 H1N1 influenza (‘swine flu’) was almost uniformly susceptible to oseltamivir. Prescribers should consider available information from the Centers for Disease Control and Prevention (CDC) on influenza drug susceptibility patterns and treatment effects when deciding whether to use oseltamivir.

 

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Hydroxyurea Capsules

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Hydroxyurea Capsules
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Product Details:
Packaging Size10x10 Capsules
BrandCytodrox
CompositionHydroxyurea
ManufacturerCipla
TreatmentCancer
Prescription/Non prescriptionPrescription
FormCapsules

Indications:
  • Melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary
  • Concomitantly with irradiation therapy in the local control of cervical cancer and primary squamous cell (epidermoid) carcinomas of the head and neck, excluding the lip

Most Common Adverse Reactions:

  • Bone marrow suppression (leucopenia, anaemia, and thrombocytopenia), gastrointestinal symptoms (stomatitis, anorexia, nausea, vomiting, diarrhoea, constipation) and dermatological reactions (maculopapular rash, skin ulceration, dermatomyositis-like skin changes, peripheral and facial erythema)
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Fluoxetine Hydrochloride Capsules

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Fluoxetine Hydrochloride Capsules
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Product Details:
Packaging Size10x10 Capsules
BrandFlutin
ManufacturerElfin
CompositionFluoxetine Hydrochloride
TreatmentDepression,Panic Attacks,Obsessive Compulsive Disorder Etc
Prescription/Non prescriptionPrescription
FormCapsules
Strength20 mg

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Isotretinoin Capsules

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Isotretinoin Capsules
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Product Details:
BrandAccufine
Packaging Size1x10 Softgel Capsules
Strength40 mg
ManufactureHealing Pharma
CompositionIsotretinoin
TreatmentAcne

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